|Calculated MW||36.6 kDa|
|Other Names||IL20, NIRF|
|Sequence||MQPRSPKSKR KGQGRPGPLA PGPHQVPLDL VSRMKPYARM EEYERNIEEM VAQLRNSSEL AQRKCEVNLQ LWMSNKRSLS PWGYSINHDP SRIPVDLPEA RCLCLGCVNP FTMQEDRSMV SVPVFSQVPV RRRLCPPPPR TGPCRQRAVM ETIAVGCTCI F|
|Application Notes||Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.|
|Storage||-20°C; Sterile filtered through a 0.2 micron filter. Lyophilized from 1x PBS, pH 7.5.|
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Provided below are standard protocols that you may find useful for product applications.
IL-17B is a disulfide-linked homodimer of two 161 amino acid polypeptide chains. It belongs to the IL-17 family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17B is expressed by T-cells and has been shown to stimulate release of TNF-α and IL-1β from cells of the monocyte lineage. Recombinant human IL-17B is a 36.6 kDa nondisulfide-linked homodimer of two 161 amino acid polypeptide chains.
Presnell S.,et al.Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
Shi Y.,et al.J. Biol. Chem. 275:19167-19176(2000).
Li H.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:773-778(2000).
Moore E.E.,et al.Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
Zhang W.,et al.Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
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