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CTGFL/WISP-2, Human recombinant protein

Connective Tissue Growth Factor-Like protein, CCN5, CT-58

     
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Product info
Primary Accession O76076
Calculated MW 24.3 kDa
Additional Info
Gene ID 8839
Gene Symbol CTGFL
Other Names Connective Tissue Growth Factor-Like protein, CCN5, CT-58
Gene Source Human
Source E.coli
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 HPLC;
Recombinant Yes
Sequence MQLCPTPCTC PWPPPRCPLG VPLVLDGCGC CRVCARRLGE PCDQLHVCDA SQGLVCQPGA GPGGRGALCL LAEDDSSCEV NGRLYREGET FQPHCSIRCR CEDGGFTCVP LCSEDVRLPS WDCPHPRRVE VLGKCCPEWV CGQGGGLGTQ PLPAQGPQFS GLVSSLPPGV PCPEWSTAWG PCSTTCGLGM ATRVSNQNRF CRLETQRRLC LSRPCPPSRG RSPQNSAF
Target/Specificity CTGFL/WISP-2
Application Notes Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not raise to neutral pH. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Format Lyophilized powder
Storage -20°C; Sterile filtered through a 0.2 micron filter. Lyophilized with no additives.
Citations (0)

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Background

CTGFL/WISP-2 is a 28.6 kDa protein that belongs to the CCN family of cysteine rich regulatory proteins. Members of this family stimulate mitosis, adhesion, apoptosis, extracellular matrix production, growth arrest, and migration of multiple cell types. The protein is expressed in primary osteoblasts, fibroblasts, ovary, testes, and heart. In addition to promoting adhesion of osteoblasts, CTGFL/WISP-2 inhibits osteocalcin production, as well as binding of fibrinogen to integrin receptors. Recombinant human CTGFL/WISP-2 is a 24.3 kDa protein of 228 amino acid residues.

References

Kumar S.,et al.J. Biol. Chem. 274:17123-17131(1999).
Rowles J.,et al.Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.
Pennica D.,et al.Proc. Natl. Acad. Sci. U.S.A. 95:14717-14722(1998).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 170.00
$ 745.00
Cat# PBV10764r
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