|Calculated MW||18.7 kDa|
|Other Names||Fibroblast Growth Factor-6, HBGF-6, HST-2|
|Sequence||MGTRANNTLL DSRGWGTLLS RSRAGLAGEI AGVNWESGYL VGIKRQRRLY CNVGIGFHLQ VLPDGRISGT HEENPYSLLE ISTVERGVVS LFGVRSALFV AMNSKGRLYA TPSFQEECKF RETLLPNNYN AYESDLYQGT YIALSKYGRV KRGSKVSPIM TVTHFLPRI|
|Application Notes||Centrifuge the vial prior to opening. Reconstitute in water to a concentration of ≤ 0.5 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.|
|Storage||-20°C; Sterile filtered through a 0.2 micron filter. Lyophilized from 10 mM Tris, pH 7.5, and 50 mM NaCl.|
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Provided below are standard protocols that you may find useful for product applications.
FGF-6 is a secreted heparin binding growth factor that is a member of the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-6 is expressed in leukemia cell lines with platelet megakaryocytic differentiation potential. It signals through FGFR 1c, 2c, and 4. Recombinant human FGF-6 is an 18.7 kDa protein consisting of 168 amino acid residues.
Coulier F.,et al.Oncogene 6:1437-1444(1991).
Iida S.,et al.Oncogene 7:303-309(1992).
Marics I.,et al.Oncogene 4:335-340(1989).
Ornitz D.M.,et al.J. Biol. Chem. 271:15292-15297(1996).
Turner N.,et al.Nat. Rev. Cancer 10:116-129(2010).
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