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IFN-λ2, human recombinant protein
IL-28A
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8IZJ0 |
|---|---|
| Calculated MW | 19.6 kDa |
| Gene ID | 282616 |
|---|---|
| Gene Symbol | IFNL2 |
| Other Names | IL-28A |
| Gene Source | Human |
| Source | E Coli |
| Assay&Purity | SDS-PAGE; ≥98% |
| Assay2&Purity2 | HPLC; |
| Recombinant | Yes |
| Sequence | PVARLHGALP DARGCHIAQF KSLSPQELQA FKRAKDALEE SLLLKDCRCH SRLFPRTWDL RQLQVRERPM ALEAELALTL KVLEATADTD PALVDVLDQP LHTLHHILSQ FRACIQPQPT AGPRTRGRLH HWLYRLQEAP KKESPGCLEA SVTFNLFRLL TRDLNCVASG DLCV |
| Target/Specificity | IFN-λ2 |
| Application Notes | Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.5-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C. |
| Format | Lyophilized powder |
| Storage | -20°C; Sterile filtered through a 0.2 micron filter. Lyophilized from 10 mM Acetic Acid. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
IFN λ-1,-2, and -3 (also known as IL-29, IL-28A and IL-28B respectively) are distantly related to the IL-10 family and Interferons. All three IFN-lambdas uses a distinct receptor system composed of an IFN-λR1 subunit (also called CRF2-12) and IL-10R2 subunit (also called CRF2-14). Signaling through this receptor system induces antiviral defense similar but distinct than the type I Interferons. Recombinant human IFN-λ2 is a 19.6 kDa protein containing 174 amino acid residues.
References
Sheppard P.,et al.Nat. Immunol. 4:63-68(2003).
Zhu H.,et al.Virol. J. 2:80-80(2005).
Kotenko S.V.,et al.Nat. Immunol. 4:69-77(2003).
Li M.C.,et al.Acta Pharmacol. Sin. 27:453-459(2006).
Donnelly R.P.,et al.J. Interferon Cytokine Res. 30:555-564(2010).
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