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>   home   >   Products   >   Proteins   >   Human CellExp SERPIN A8, human recombinant protein   

Human CellExp SERPIN A8, human recombinant protein

Angiotensinogen, SerpinA8, AGT, ANHU

     
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Product info
Primary Accession P01019
Calculated MW The protein is fused with 6×His tag at the N-terminus, has a calculated MW of 50.6 kDa. The predicted N-terminus is Asp 34. DTT-reduced Protein migrates as 55-60 kDa due to glycosylation.
Additional Info
Gene ID 183
Gene Symbol AGT
Other Names Angiotensinogen, SerpinA8, AGT, ANHU
Gene Source Human
Source HEK 293 cells
Assay&Purity SDS-PAGE; ≥98%
Assay2&Purity2 HPLC;
Recombinant Yes
Target/Specificity SERPINA8
Application Notes Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
Format Lyophilized powder
Storage -20°C; Lyophilized from 0.22 µm filtered solution in PBS. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.
Citations (0)

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Background

Serpin A8 also known as angiotensinogen (AGT) , is a member of the serpin family. It is an α-2-globulin that is expressed by the liver and secreted in plasma. As essential component of the renin-angiotensin system (RAS), Angiotensinogen is cleaved into three chains: Angiotensin-1 (Ang I), Angiotensin-2 (Ang II), and Angiotensin-3 (Ang III) in lowered blood pressure by the enzyme renin. Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2. Angiotensin-2 acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone. Angiotensin-3 stimulates aldosterone release. Defects in AGT are a cause of renal tubular dysgenesis (RTD).

References

Kageyama R.,et al.Biochemistry 23:3603-3609(1984).
Gaillard I.,et al.DNA 8:87-99(1989).
Fukamizu A.,et al.J. Biol. Chem. 265:7576-7582(1990).
Kunapuli S.P.,et al.Circ. Res. 60:786-790(1987).
Kunapuli S.P.,et al.Arch. Biochem. Biophys. 254:642-646(1987).

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$ 235.00
Cat# PBV10866r
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