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>   home   >   Products   >   Proteins   >   Human CellExp GAD1, human recombinant protein   

Human CellExp GAD1, human recombinant protein


Product info
Primary Accession Q99259
Calculated MW This protein is fused with 6×his tag at C-terminus, has a calculated MW of 67 kDa expressed. The predicted N-terminus is Met1. Protein migrates as the predominant 64 kDa form and a less-frequent 24-kDa form in reduced SDS-PAGE resulting from alternative splicing.
Additional Info
Gene ID 2571
Gene Symbol GAD1
Other Names GAD1, CPSQ1, GAD, SCP, GAD-1, CPSQ-1, GAD67, GAD-67
Gene Source Human
Source HEK 293 cells
Assay&Purity SDS-PAGE; ≥92%
Assay2&Purity2 HPLC;
Recombinant Yes
Target/Specificity GAD1
Application Notes Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
Format Lyophilized powder
Storage -20°C; Lyophilized from 0.22 µm filtered solution in PBS, pH 7.4, 1 mM EDTA with some stabilizer. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.
Citations (0)

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Glutamate decarboxylase 1 (GAD1), also known as 67 kDa glutamic acid decarboxylase and Glutamate decarboxylase 67 kDa isoform, is a member of the group II decarboxylase family. GAD1 is expressed in benign and malignant prostatic tissue and may serve as a highly prostate-specific tissue biomarker. GAD1 is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. GAD1 may also play a role in the stiff man syndrome. Defects in GAD1 are the cause of cerebral palsy spastic quadriplegic type 1 (CPSQ1) which is a non-progressive disorder of movement and/or posture resulting from defects in the developing central nervous system. GAD1 has been shown to interact with GAD2. Affected individuals manifest symmetrical, non-progressive spasticity and no adverse perinatal history or obvious underlying alternative diagnosis.


Bu D.-F.,et al.Proc. Natl. Acad. Sci. U.S.A. 89:2115-2119(1992).
Bu D.-F.,et al.Genomics 21:222-228(1994).
Kelly C.D.,et al.Lancet 338:1468-1469(1991).
Kelly C.D.,et al.Ann. Hum. Genet. 56:255-265(1992).
Yamashita K.,et al.Biochem. Biophys. Res. Commun. 192:1347-1352(1993).

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$ 235.00
$ 895.00
Cat# PBV10880r
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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