Human CellExp IL-22, human recombinant protein
IL-22, IL-TIF, ZCYTO18
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9GZX6 |
---|---|
Calculated MW | Calculated MW of 17.2 kDa with no tag. The predicted N-terminus is Ala 34. DTT-reduced protein migrates as 18-33 kDa due to glycosylation. |
Gene ID | 50616 |
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Gene Symbol | IL-22 |
Other Names | IL-22, IL-TIF, ZCYTO18 |
Gene Source | Human |
Source | HEK 293 cells |
Assay&Purity | SDS-PAGE; ≥95% |
Assay2&Purity2 | N/A; |
Recombinant | Yes |
Target/Specificity | IL-22 |
Application Notes | Centrifuge the vial prior to opening. Reconstitute in sterile deionized water to a concentration of 100 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C. |
Format | Lyophilized powder |
Storage | -20°C; Lyophilized from 0.22 µm filtered solution in 20 mM Tris, 100 mM NaCl, pH 8.0. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Interleukin-22 (IL22) is also known as cytokine Zcyto18, IL-10-related T-cell-derived-inducible factor (IL-TIF), which is belongs to the IL-10 family or IL-10 superfamily (including IL-19, IL-20, IL-24, and IL-26), a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells and initiates innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 biological activity is initiated by binding to a cell-surface complex composed of IL-22R1 and IL-10R2 receptor chains and further regulated by interactions with a soluble binding protein IL-22BP. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10.
References
Dumoutier L.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:10144-10149(2000).
Dumoutier L.,et al.Genes Immun. 1:488-494(2000).
Xie M.-H.,et al.J. Biol. Chem. 275:31335-31339(2000).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Zhang Z.,et al.Protein Sci. 13:2819-2824(2004).
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