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Apolipoprotein AII, Human Plasma recombinant protein
Apolipoprotein A-II, Apo-AII, ApoA-II, APOA2.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P02652 |
|---|---|
| Calculated MW | 17.4 kDa |
| Gene ID | 336 |
|---|---|
| Gene Symbol | ApoA2 |
| Other Names | Apolipoprotein A-II, Apo-AII, ApoA-II, APOA2. |
| Gene Source | Human |
| Source | Human plasma. Prepared from plasma shown to be non-reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests. |
| Assay&Purity | SDS-PAGE; ≥ 95% by SDS - PAGE |
| Assay2&Purity2 | N/A; |
| Recombinant | No |
| Target/Specificity | ApoA2 |
| Format | Frozen |
| Storage | -80°C; Frozen in 10 mM NH4HCO3, pH 7.4 |
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Provided below are standard protocols that you may find useful for product applications.
Background
APOA2 stabilizes the HDL structure by its relationship with lipids, and plays a role in the HDL metabolism. APOA2 is the 2nd most abundant protein of the high density lipoprotein particles. 25% of Apo A in HDL is Apo AII. APOA2 is localized in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in APOA2 gene might cause apolipoprotein A-II deficiency or hypercholesterolemia. Levels of Apo AII in normal plasma range from 30-50 mg per 100 ml. The physiological role of the protein is unknown. Alcohol consumption, however, increases Apo AII levels.
References
Knott T.J.,et al.Biochem. Biophys. Res. Commun. 120:734-740(1984).
Moore M.N.,et al.Biochem. Biophys. Res. Commun. 123:1-7(1984).
Sharpe C.R.,et al.Nucleic Acids Res. 12:3917-3932(1984).
Lackner K.J.,et al.Nucleic Acids Res. 13:4597-4608(1985).
Knott T.J.,et al.Nucleic Acids Res. 13:6387-6398(1985).
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