|Calculated MW||17.4 kDa|
|Other Names||Apolipoprotein A-II, Apo-AII, ApoA-II, APOA2.|
|Source||Human plasma. Prepared from plasma shown to be non-reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.|
|Assay&Purity||SDS-PAGE; ≥ 95% by SDS - PAGE|
|Storage||-80°C; Frozen in 10 mM NH4HCO3, pH 7.4|
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Provided below are standard protocols that you may find useful for product applications.
APOA2 stabilizes the HDL structure by its relationship with lipids, and plays a role in the HDL metabolism. APOA2 is the 2nd most abundant protein of the high density lipoprotein particles. 25% of Apo A in HDL is Apo AII. APOA2 is localized in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in APOA2 gene might cause apolipoprotein A-II deficiency or hypercholesterolemia. Levels of Apo AII in normal plasma range from 30-50 mg per 100 ml. The physiological role of the protein is unknown. Alcohol consumption, however, increases Apo AII levels.
Knott T.J.,et al.Biochem. Biophys. Res. Commun. 120:734-740(1984).
Moore M.N.,et al.Biochem. Biophys. Res. Commun. 123:1-7(1984).
Sharpe C.R.,et al.Nucleic Acids Res. 12:3917-3932(1984).
Lackner K.J.,et al.Nucleic Acids Res. 13:4597-4608(1985).
Knott T.J.,et al.Nucleic Acids Res. 13:6387-6398(1985).
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