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Lactalbumin, Human Milk recombinant protein
LYZL7
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P00709 |
|---|---|
| Calculated MW | 14 kDa |
| Gene ID | 3906 |
|---|---|
| Gene Symbol | LYZL7 |
| Other Names | LYZL7 |
| Gene Source | Human |
| Source | Human Milk. Prepared from Human Milk shown to be non-reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA required tests. |
| Assay&Purity | SDS-PAGE; ≥95% |
| Assay2&Purity2 | N/A; |
| Recombinant | No |
| Target/Specificity | Lactalbumin |
| Application Notes | Use deionized water |
| Format | Lyophilized |
| Storage | 4°C; Lyophilized from de-ionized water |
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Provided below are standard protocols that you may find useful for product applications.
Background
α-Lactalbumin is an important whey protein in cow's milk, and is also present in the milk of many other mammalian species. In primates, alpha-lactalbumin expression is upregulated in response to the hormone prolactin and increases the production of lactose. α-Lactalbumin forms the regulatory subunit of the lactose synthase (LS) heterodimer and β-1,4-galactosyltransferase (beta4Gal-T1) forms the catalytic component. Together, these proteins enable LS to produce lactose by transferring galactose moieties to glucose. As a monomer, alpha-lactalbumin strongly binds calcium and zinc ions and may possess bactericidal or antitumor activity. When formed into a complex with Gal-T1, a galactosyltransferase, α-lactalbumin, enhances the enzyme's affinity for glucose by about 1000 times, and inhibits the ability to polymerize multiple galactose units. This gives rise to a pathway for forming lactose by converting Gal-TI to Lactose synthase.
References
Hall L.,et al.Nucleic Acids Res. 10:3503-3515(1982).
Hall L.,et al.Biochem. J. 242:735-742(1987).
Fujiwara Y.,et al.Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
Halleck A.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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