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Azurocidin, Human Neutrophil (Cationic protein 37) recombinant protein

Cationic antimicrobial protein CAP37, Heparin-binding protein

Product info
Primary Accession P20160
Calculated MW 37 kDa
Additional Info
Gene ID 566
Gene Symbol AZU1
Other Names Cationic antimicrobial protein CAP37, Heparin-binding protein
Gene Source Human
Source Human Neutrophil. Prepared from whole blood shown to be non-reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 N/A;
Recombinant No
Target/Specificity Azurocidin
Application Notes Use deionized water
Format Lyophilized
Storage -20°C; Salt-free lyophilized solid.
Citations (0)

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The gene for azurocidin is located on the short arm of chromosome 19 and is in a cluster with the genes for proteinase 3 and elastase. All three proteins are serine protease homologues; azurocidin, however, lacks enzymatic activity. It is an antibiotic protein, with monocyte chemotactic and antibacterial activity. The Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of microorganisms. Azurocidin is a member of the serine protease family that includes Cathepsin G, Neutrophil Elastase (NE), and Proteinase 3 (PR3), however, Azurocidin is not a serine proteinase since the active site serine and histidine residues are replaced. Azurocidin has been identified as a modulator of endothelial permeability and an important multifunctional inflammatory mediator. Neutrophils arriving first at sites of inflammation release Azurocidin which acts in a paracrine fashion on endothelial cells causing the development of intercellular gaps and allowing leukocyte extravasation. Azurocidin thus be regarded as a reasonable therapeutic target for a variety of inflammatory disease conditions.


Morgan J.G.,et al.J. Immunol. 147:3210-3214(1991).
Zimmer M.,et al.Proc. Natl. Acad. Sci. U.S.A. 89:8215-8219(1992).
Grimwood J.,et al.Nature 428:529-535(2004).
Almeida R.P.,et al.Biochem. Biophys. Res. Commun. 177:688-695(1991).
Pohl J.,et al.FEBS Lett. 272:200-204(1990).

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$ 265.00
Cat# PBV10911r-100
Availability: 5-7days
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