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Bacterial/Permeability-Increasing Protein, Human Neutrophil (BPI, CAP57) recombinant protein


Product info
Primary Accession P17213
Calculated MW 55 kDa
Additional Info
Gene ID 671
Gene Symbol BPI
Other Names BPI, CAP57
Gene Source Human
Source Human Neutrophil
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 N/A;
Recombinant No
Target/Specificity BPI
Format Frozen
Storage -80°C; Frozen in 80 mM Citrate Phosphate, pH 5.6, 0.75 M NaCl.
Citations (0)

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Bactericidal/permeability increasing protein (BPI) is a 456 residue protein which is part of the innate immune system. BPI was initially identified in neutrophils, but is found in other tissues including the epithelial lining of mucus membranes. It is an endogenous antibiotic protein with potent killing activity against Gram-negative bacteria. It binds to compounds called lipopolysaccharides produced by Gram-negative bacteria. Lipolysaccharides are potent activators of the immune system; however BPI at certain concentrations can prevent this activation. Bacterial/Permeability-Increasing Protein (BPI) is present in the azurophilic granules of polymorphonuclear leukocytes (PMN). BPI is toxic only toward Gram-negative bacteria. This specificity is attributable to the strong attraction of BPI for the lipopolysaccharides (LPS) in the bacterial envelope. BPI is also an important antigen for anti-neutrophil cytoplasmic autoantibodies (ANCA) in vasculitis.


Gray P.W.,et al.J. Biol. Chem. 264:9505-9509(1989).
Wilde C.G.,et al.J. Biol. Chem. 269:17411-17416(1994).
Ma H.,et al.Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Deloukas P.,et al.Nature 414:865-871(2001).

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$ 195.00
$ 355.00
Cat# PBV10912r
(40 western blots)
Availability: 5-7days
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