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Alpha 2 Antiplasmin, Human Plasma recombinant protein

Alpha-2-plasmin inhibitor, SERPINF2, AAP, PLI

Product info
Primary Accession P08697
Calculated MW 70 kDa
Additional Info
Gene ID 5345
Gene Symbol SERPINF2
Other Names Alpha-2-plasmin inhibitor, SERPINF2, AAP, PLI
Gene Source Human
Source Human Plasma
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 N/A;
Recombinant No
Target/Specificity SERPINF2
Application Notes In water or aqueous buffer
Format Lyophilized
Storage -20°C; Lyophilized from 20 mM Bis-Tris, pH 6.4, with 200 mM NaCl.
Citations (0)

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Alpha 2 Antiplasmin is a member of the Serpin superfamily and the primary physiological inhibitor of the serine protease plasmin, which is responsible for the dissolution of fibrin clots. In addition to plasmin, it is also an efficient inhibitor of trypsin and chymotrypsin. Liver and kidney are major sites of its production and other tissues such as muscle, intestine, central nervous system, and placenta also express its mRNA at a moderate level. The tissue expression pattern indicates that it is a key regulator of plasmin mediated proteolysis in these tissues. Alpha-Antiplasmin-deficiency is a rare coagulation disorder which allows unrestrained fibrinolytic activity. Individuals with this condition may receive therapeutic A2AP prior to surgery to prevent postoperative hemorrhaging.


Tone M.,et al.J. Biochem. 102:1033-1041(1987).
Hirosawa S.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:6836-6840(1988).
Hirosawa S.,et al.Proc. Natl. Acad. Sci. U.S.A. 86:1612-1613(1989).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:1045-1049(2006).

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$ 90.00
Cat# PBV10919r
(40 western blots)
Availability: 5-7days
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