Kininogen, HMW, Human Plasma recombinant protein
Alpha-2-thiol proteinase inhibitor, Fitzgerald factor, High molecular weight Kininogen, Williams-Fit
|Calculated MW||120 kDa|
|Other Names||Alpha-2-thiol proteinase inhibitor, Fitzgerald factor, High molecular weight Kininogen, Williams-Fitzgerald-Flaujeac factor, BDK, KNG, Kininogen-1 heavy chain, T-kinin, Bradykinin, Lysyl-bradykinin, Kininogen-1 light chain, Low molecular weight growth-promoting factor|
|Storage||-80°C; Frozen in 10 mM Na acetate, pH 5.5 with 250 mM NaCI.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
HMW kininogen, synthesized by hepatocytes, is a multifunctional protein. It is the precursor protein of bradykinin. In addition it is a cofactor in the activation of factor XI, XII, and prekallikrein and a major extra-cellular cysteine proteinase inhibitor. Kininogens inhibit systemic proteases which are thought to have a part in various diseases such as cancer, muscular dystrophy and joint disease.
Ohkubo I.,et al.Biochemistry 23:5691-5697(1984).
Takagaki Y.,et al.J. Biol. Chem. 260:8601-8609(1985).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Totoki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Muzny D.M.,et al.Nature 440:1194-1198(2006).
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