CD274, mouse recombinant protein
CD274 antigen, A530045L16Rik, B7h1, Pdcd1l1, Pdcd1lg1, Pdl1
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9EP73 |
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Concentration | 1 |
Calculated MW | 27.6 kDa (246 aa, 19-239 aa + His tag), confirmed by MALDI-TOF. |
Gene ID | 60533 |
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Gene Symbol | CD274 |
Other Names | CD274 antigen, A530045L16Rik, B7h1, Pdcd1l1, Pdcd1lg1, Pdl1 |
Gene Source | Mouse |
Source | E. coli |
Assay&Purity | SDS-PAGE; ≥85% |
Assay2&Purity2 | N/A; |
Recombinant | Yes |
Sequence | MGSSHHHHHH SSGLVPRGSH MGSHM RASLPKDQLL KGNAALQITD VKLQDAGVYC CIISYGGADY KRITLKVNAP YRKINQRISV DPATSEHELI CQAEGYPEAE VIWTNSDHQP FTITA PKDLYVVEYG SNVTMECRFP VERELDLLAL VVYWEKEDEQ VIQFVAGEED LKPQHSNFRG VSGKRSVTTS RTEGMLLNVT SSLRVNATAN DVFYCTFWRS QPGQNHTAEL IIPELPATHP PQNRTH |
Target/Specificity | CD274 |
Format | Liquid |
Storage | -80°C; 1 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 0.15 M NaCl and 10% glycerol. |
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Provided below are standard protocols that you may find useful for product applications.
Background
CD274, also known as programmed cell death 1 ligand 1(PDCD1L1), is involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. This protein interacts with PDCD1 inhibits T-cell proliferation and cytokine production. Recombinant mouse CD274 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
References
Freeman G.J.,et al.J. Exp. Med. 192:1027-1034(2000).
Tamura H.,et al.Blood 97:1809-1816(2001).
Latchman Y.,et al.Nat. Immunol. 2:261-268(2001).
Wang S.,et al.J. Exp. Med. 197:1083-1091(2003).
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