|Calculated MW||23.3 kDa (209 aa, 21-205 aa + His Tag), confirmed by MALDI-TOF.|
|Other Names||Triggering receptor expressed on myeloid cells 1, CD354, TREM-1|
|Sequence||MGSSHHHHHH SSGLVPRGSH MGSM ATKLTE EKYELKEGQT LDVKCDYTLE KFASSQKAWQ IIRDGEMPKT LACTERPSKN SHPVQVGRII LEDYHDHGLL RVRMVNLQVE DSGLYQCVIY QPPKEPHMLF DRIRLVVTKG FSGTPGSNEN STQNVYKIPP TTTKALCPLY TSPRTVTQAP PKSTADVSTP DSEINLTNVT DIIRVPVFN|
|Storage||-80°C; 0.5 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 0.15 M NaCl, 30% glycerol and 1 mM DTT.|
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Provided below are standard protocols that you may find useful for product applications.
TREM1 is a receptor belonging to the Ig super family that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. Recombinant human TREM1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Bouchon A.,et al.J. Immunol. 164:4991-4995(2000).
Gingras M.-C.,et al.Mol. Immunol. 38:817-824(2002).
Begum N.A.,et al.Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mungall A.J.,et al.Nature 425:805-811(2003).
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