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CD247, human recombinant protein
T-cell surface glycoprotein CD3 zeta chain, CD3-ZETA, CD3H, CD3Q, CD3Z, T3Z, TCRZ
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P20963 |
|---|---|
| Concentration | 0.5 |
| Calculated MW | 15.4 kDa (136 aa, 52-164 aa + His Tag), confirmed by MALDI-TOF. |
| Gene ID | 919 |
|---|---|
| Gene Symbol | CD247 |
| Other Names | T-cell surface glycoprotein CD3 zeta chain, CD3-ZETA, CD3H, CD3Q, CD3Z, T3Z, TCRZ |
| Gene Source | Human |
| Source | E. coli |
| Assay&Purity | SDS-PAGE; ≥90% |
| Assay2&Purity2 | N/A; |
| Recombinant | Yes |
| Sequence | MGSSHHHHHH SSGLVPRGSH MGSRVKFSRS ADAPAYQQGQ NQLYNELNLG RREEYDVLDK RRGRDPEMGG KPQRRKNPQE GLYNELQKDK MAEAYSEIGM KGERRRGKGH DGLYQGLSTA TKDTYDALHM QALPPR |
| Target/Specificity | CD247 |
| Format | Liquid |
| Storage | -80°C; 0.5 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 0.15 M NaCl, 10% glycerol and 1 mM DTT. |
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Provided below are standard protocols that you may find useful for product applications.
Background
T-cell surface glycoprotein CD3 zeta chain, also known as CD247, belongs to the CD3Z/FCER1G family. CD247 is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Recombinant human CD247 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
References
Weissman A.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:9709-9713(1988).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Howe A.Y.,et al.J. Virol. 72:9827-9834(1998).
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