|Calculated MW||30.0 kDa (271 aa, 1-247 aa + His Tag), confirmed by MALDI-TOF.|
|Other Names||Fibroblast growth factor 14 isoform 1A, FGF-14, FHF-4, FHF4, SCA27|
|Sequence||MGSSHHHHHH SSGLVPRGSH MGSHMAAAIA SGLIRQKRQA REQHWDRPSA SRRRSSPSKN RGLCNGNLVD IFSKVRIFGL KKRRLRRQDP QLKGIVTRLY CRQGYYLQMH PDGALDGTKD DSTNSTLFNL IPVGLRVVAI QGVKTGLYIA MNGEGYLYPS ELFTPECKFK ESVFENYYVI YSSMLYRQQE SGRAWFLGLN KEGQAMKGNR VKKTKPAAHF LPKPLEVAMY REPSLHDVGE TVPKPGVTPS KSTSASAIMN GGKPVNKSKT T|
|Storage||-80°C; 0.25 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 0.2 M NaCl, 5 mM DTT and 50% glycerol.|
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Provided below are standard protocols that you may find useful for product applications.
FGF14 is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. A mutation in this gene is associated with autosomal dominant cerebral ataxia. Alternatively spliced transcript variants have been found for this gene. Recombinant human FGF14 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Smallwood P.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 93:9850-9857(1996).
Bonner T.I.,et al.Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
Chumakov I.,et al.Proc. Natl. Acad. Sci. U.S.A. 99:13675-13680(2002).
Dunham A.,et al.Nature 428:522-528(2004).
van Swieten J.C.,et al.Am. J. Hum. Genet. 72:191-199(2003).
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