|Calculated MW||18.4 kDa (162 aa, 94-231 aa + His Tag), confirmed by MALDI-TOF.|
|Other Names||NKG2-C type II integral membrane protein, CD159c, NKG2-C, NKG2C|
|Sequence||MGSSHHHHHH SSGLVPRGSH MGSM IPFLEQ NNFSPNTRTQ KARHCGHCPE EWITYSNSCY YIGKERRTWE ESLLACTSKN SSLLSIDNEE EMKFLASILP SSWIGVFRNS SHHPWVTING LAFKHKIKDS DNAELNCAVL QVNRLKSAQC GSSMIYHCKH KL|
|Storage||-80°C; 0.5 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea and 10% glycerol.|
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Provided below are standard protocols that you may find useful for product applications.
NKG2-C type II integral membrane protein, also known as KLRC2, plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. The group, designated KLRC (NKG2) are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. KLRC2 alternative splice variants have been described but their full-length nature has not been determined. Recombinant human KLRC2 protein, fused to His-tag at N-terminus, was expressed in E.coli.
Houchins J.P.,et al.J. Exp. Med. 173:1017-1020(1991).
Glienke J.,et al.Immunogenetics 48:163-173(1998).
Shum B.P.,et al.J. Immunol. 168:240-252(2002).
Biassoni R.,et al.Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases.
Scherer S.E.,et al.Nature 440:346-351(2006).
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