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TREM2, human recombinant protein

Triggering receptor expressed on myeloid cells 2, Trem2a, Trem2b, Trem2c

     
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Product info
Primary Accession Q9NZC2
Concentration 0.25
Calculated MW 20.4 kDa (181 aa, 19-161 aa + His Tag), confirmed by MALDI-TOF.
Additional Info
Gene ID 54209
Gene Symbol TREM2
Other Names Triggering receptor expressed on myeloid cells 2, Trem2a, Trem2b, Trem2c
Gene Source Human
Source E. coli
Assay&Purity SDS-PAGE; ≥90%
Assay2&Purity2 N/A;
Recombinant Yes
Sequence MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMHN TTVFQGVAGQ SLQVSCPYDS MKHWGRRKAW CRQLGEKGPC QRVVSTHNLW LLSFLRRWNG STAITDDTLG GTLTITLRNL QPHDAGLYQC QSLHGSEADT LRKVLVEVLA DPLDHRDAGD LWFPGESESF EDAHVEHSIS R
Target/Specificity TREM2
Format Liquid
Storage -80°C; 0.25 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 0.15 M NaCl, 1 mM DTT and 10% glycerol.
Citations (0)

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Background

TREM2 is a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The protein functions in immune response and maybe involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. Recombinant human TREM2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

References

Bouchon A.,et al.J. Immunol. 164:4991-4995(2000).
Begum N.A.,et al.Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
Paloneva J.,et al.Am. J. Hum. Genet. 71:656-662(2002).
Paloneva J.,et al.Am. J. Hum. Genet. 72:225-225(2003).

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$ 295.00
Cat# PBV10981r
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