TREM2, human recombinant protein
Triggering receptor expressed on myeloid cells 2, Trem2a, Trem2b, Trem2c
|Calculated MW||20.4 kDa (181 aa, 19-161 aa + His Tag), confirmed by MALDI-TOF.|
|Other Names||Triggering receptor expressed on myeloid cells 2, Trem2a, Trem2b, Trem2c|
|Sequence||MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMHN TTVFQGVAGQ SLQVSCPYDS MKHWGRRKAW CRQLGEKGPC QRVVSTHNLW LLSFLRRWNG STAITDDTLG GTLTITLRNL QPHDAGLYQC QSLHGSEADT LRKVLVEVLA DPLDHRDAGD LWFPGESESF EDAHVEHSIS R|
|Storage||-80°C; 0.25 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 0.15 M NaCl, 1 mM DTT and 10% glycerol.|
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TREM2 is a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The protein functions in immune response and maybe involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. Recombinant human TREM2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Bouchon A.,et al.J. Immunol. 164:4991-4995(2000).
Begum N.A.,et al.Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
Paloneva J.,et al.Am. J. Hum. Genet. 71:656-662(2002).
Paloneva J.,et al.Am. J. Hum. Genet. 72:225-225(2003).
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