|Calculated MW||37.9 kDa (337 aa, 1-317 aa + His Tag).|
|Other Names||Gal-8, PCTA1, Po66-CBP, Prostate carcinoma tumor antigen 1|
|Sequence||MGSSHHHHHH SSGLVPRGSH MMLSLNNLQN IIYNPVIPFV GTIPDQLDPG TLIVIRGHVP SDADRFQVDL QNGSSMKPRA DVAFHFNPRF KRAGCIVCNT LINEKWGREE ITYDTPFKRE KSFEIVIMVL KDKFQVAVNG KHTLLYGHRI GPEKIDTLGI YGKVNIHSIG FSFSSDLQST QASSLELTEI SRENVPKSGT PQLRLPFAAR LNTPMGPGRT VVVKGEVNAN AKSFNVDLLA GKSKDIALHL NPRLNIKAFV RNSFLQESWG EEERNITSFP FSPGMYFEMI IYCDVREFKV AVNGVHSLEY KHRFKELSSI DTLEINGDIH LLEVRSW|
|Storage||-80°C; 0.5 mg/ml in 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM DTT, 0.1 M NaCl and 10% glycerol.|
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Provided below are standard protocols that you may find useful for product applications.
LGALS8, also known as prostate-specific membrane antigen (PCTA1), is an additional prostate-specific antigen that is overexpressed only in malignant tumors and therefore is a more specific identifier of malignancies. It is a member of the galectin gene family which mediates both cell-cell and cell matrix interactions in a manner similar to the selectin subgroup of C-type lectins. Recombinant human LGALS8 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Su Z.-Z.,et al.Proc. Natl. Acad. Sci. U.S.A. 93:7252-7257(1996).
Hadari Y.R.,et al.Trends Glycosci. Glycotechnol. 9:103-112(1997).
Brichory F.,et al.Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.
Maier C.,et al.Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
Gopalkrishnan R.V.,et al.Oncogene 19:4405-4416(2000).
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