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Human CellExp CD319 / SLAMF7 / CRACC, human recombinant protein
SLAMF7, CD319, CS1, CRACC, 19A, FOAP-12
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9NQ25 |
|---|---|
| Calculated MW | This protein is fused with 6×His tag at the C-terminus, has a calculated MW of 23.2 kDa. The predicted N-terminus is Ser 23. DTT-reduced Protein migrates as 33-48 kDa due to glycosylation. |
| Gene ID | 57823 |
|---|---|
| Gene Symbol | SLAMF7 |
| Other Names | SLAMF7, CD319, CS1, CRACC, 19A, FOAP-12 |
| Gene Source | Human |
| Source | HEK293 cells |
| Assay&Purity | SDS-PAGE; ≥95% |
| Assay2&Purity2 | N/A; |
| Recombinant | Yes |
| Results | Measured by its ability to bind biotinylated human SLAMF7 in a functional ELISA. |
| Target/Specificity | CD319/SLAMF7/CRACC |
| Application Notes | Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C. |
| Format | Lyophilized |
| Storage | -20°C; Lyophilized from 0.22 µm filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization. |
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Provided below are standard protocols that you may find useful for product applications.
Background
SLAM family member 7 (SLAMF7) is also known as CD2-like receptor-activating cytotoxic cells (CRACC), Membrane protein FOAP-12, CD antigen CD319, Novel Ly9, Protein 19A, which is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 is expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. Isoform 1 of SLAMF7 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway. May play a role in lymphocyte adhesion. Isoform 3 of SLAMF7 does not mediate any NK cell activation.
References
Boles K.S.,et al.Immunogenetics 52:302-307(2001).
Bouchon A.,et al.J. Immunol. 167:5517-5521(2001).
Murphy J.J.,et al.Biochem. J. 361:431-436(2002).
Fujii Y.,et al.Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
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