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>   home   >   Products   >   Proteins   >   Human CellExp CD62E/E-Selectin, human recombinant protein   

Human CellExp CD62E/E-Selectin, human recombinant protein

SELE, RP1-117P20.2, CD62E, ELAM1, ESEL, LECAM2, E-Selectin

Product info
Primary Accession P16581
Calculated MW This protein is fused with a 6×his tag at C-terminus and has a calculated MW of 60 kDa expressed. The predicted N-terminus is Trp22. Protein migrates as 110 kDa in reduced SDS-PAGE resulting from glycosylation.
Additional Info
Gene ID 6401
Gene Symbol SELE
Other Names SELE, RP1-117P20.2, CD62E, ELAM1, ESEL, LECAM2, E-Selectin
Gene Source Human
Source HEK293 cells
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 N/A;
Recombinant Yes
Results Measured by the ability of the immobilized protein to support the adhesion of U937 human histiocytic lymphoma cells. When 5 x 10^4 cells/well are added to human E-Selectin coated plates (2 µg/mL with 100 µL/well), >80% cells will adhere after 1 hour incubation at 37°C.
Target/Specificity CD62E/E-Selectin
Application Notes Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
Format Lyophilized
Storage -20°C; Lyophilized from 0.22 µm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.
Citations (0)

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E-Selectin, also known as CD62 antigen-like family member E (CD62E), endothelial-leukocyte adhesion molecule 1 (ELAM-1), or leukocyte-endothelial cell adhesion molecule 2 (LECAM2), a member of the Selectin family, is a 107-115 kDa cell surface glycoprotein. It is transiently expressed on vascular endothelial cells in response to IL-1β and TNFα. E selectin has a cassette structure: an N-terminal, C-type lectin domain, an EGF (epidermal-growth-factor)-like domain, 6 Sushi domain (SCR repeat) units, a transmembrane domain (TM) and an intracellular cytoplasmic tail (cyto). During inflammation, E-selectin plays an important part in recruiting leukocytes to the site of injury. The local release of cytokines IL-1 and TNF-α by damaged cells induces the over-expression of E-selectin on endothelial cells of nearby blood vessels. E-selectin mediates the adhesion of tumor cells to endothelial cells, by binding to E-selectin ligands expressed by neutrophils, monocytes, eosinophils, memory-effector T-like lymphocytes, natural killer cells or cancer cells. Furthermore, a number of studies have reported that levels of E-Selectin may be elevated in subjects with a variety of pathological conditions.


Hession C.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:1673-1677(1990).
Bevilacqua M.P.,et al.Science 243:1160-1165(1989).
Collins T.,et al.J. Biol. Chem. 266:2466-2473(1991).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

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$ 195.00
$ 595.00
Cat# PBV11055r
(40 western blots)
Availability: 5-7days
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