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>   home   >   Products   >   Proteins   >   Human CellExp GFRA2 /GDNFRB, human recombinant protein   

Human CellExp GFRA2 /GDNFRB, human recombinant protein


Product info
Primary Accession O00451
Calculated MW This protein is fused with 6×His tag at the N-terminus, has a calculated MW of 47.6 kDa. The predicted N-terminus is Ser 22. DTT-reduced Protein migrates as 60-70 KDa due to glycosylation.
Additional Info
Gene ID 2675
Gene Symbol GFRA2
Gene Source Human
Source HEK293 cells
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 N/A;
Recombinant Yes
Results Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human Neurturin at 1 µg/ml can bind rhGFRA2 with an apparent KD < 8 nM.
Target/Specificity GFRA2 /GDNFRB
Application Notes Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
Format Lyophilized
Storage -20°C; Lyophilized from 0.22 µm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.
Citations (0)

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GDNF family receptor alpha-2 (GFRA2) also known as GDNF receptor beta, Neurturin receptor alpha, RET ligand 2, TGF-beta-related neurotrophic factor receptor 2, is a cell membrane protein which belongs to the GDNFR family. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GDNF is a glycosylated, disulfide-bonded homodimer that is distantly related to the TGF-beta superfamily of growth factors. Three receptors for these factors, GFRα-1, GFRα-2 and GFRα-3 have been identified. The isoform 1 of GFRA2 is found in both brain and placenta. GFRA2 mediates the NRTN-induced autophosphorylation and activation of the RET receptor and also able to mediate GDNF signaling through the RET tyrosine kinase receptor. GFRA2 mediates the NRTN-induced autophosphorylation and activation of the RET receptor. It can also mediate GDNF signaling through the RET tyrosine kinase receptor.


Baloh R.H.,et al.Neuron 18:793-802(1997).
Suvanto P.,et al.Hum. Mol. Genet. 6:1267-1273(1997).
Sanicola M.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:6238-6243(1997).
Yoong L.F.,et al.Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
Nusbaum C.,et al.Nature 439:331-335(2006).

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$ 195.00
$ 595.00
Cat# PBV11091r
(40 western blots)
Availability: 5-7days
Bulk Size
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