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Human CellExp FABP2 /I-FABP, human recombinant protein
FABP2, FABPI, I-FABP
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P12104 |
|---|---|
| Calculated MW | This protein is fused with 6×His tag at the N-terminus, has a calculated MW of 16 kDa. The predicted N-terminus is Ala 2. DTT-reduced Protein migrates as 16 kDa. |
| Gene ID | 2169 |
|---|---|
| Gene Symbol | FABP2 |
| Other Names | FABP2, FABPI, I-FABP |
| Gene Source | Human |
| Source | HEK293 cells |
| Assay&Purity | SDS-PAGE; ≥98% |
| Assay2&Purity2 | N/A; |
| Recombinant | Yes |
| Results | The binding affinity of Recombinant Human FABP2/I‑FABP for the synthetic ligand cis-parinaric acid has been measured by fluorescence titration. Half-maximal fluorescence of 3 µM Recombinant Human FABP2/I‑FABP is achieved with approximately 3 µM cis‑paranaric acid. |
| Target/Specificity | FABP2 /I-FABP |
| Application Notes | Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C. |
| Format | Lyophilized |
| Storage | -20°C; Lyophilized from 0.22 µm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Fatty acid-binding protein 2 (FABP2), is also known as Fatty acid-binding protein, intestinal (FABPI), Intestinal-type fatty acid-binding protein (I-FABP). FABP2 belongs to the calycin superfamily and Fatty-acid binding protein (FABP) family. FABP2 / FABPI is expressed in the small intestine and at much lower levels in the large intestine and is highest expressed in the jejunum. FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. FABP2 binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.
References
Sweetser D.A.,et al.J. Biol. Chem. 262:16060-16071(1987).
Hillier L.W.,et al.Nature 434:724-731(2005).
Pelsers M.M.A.L.,et al.Clin. Biochem. 36:529-535(2003).
Darimont C.,et al.Am. J. Physiol. 276:G606-G612(1999).
Rajabzadeh M.,et al.Biochemistry 42:12192-12199(2003).
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