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Alpha 1 Acid Glycoprotein, Human Plasma recombinant protein
AGP, Orosomucoid
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P02763 |
|---|---|
| Calculated MW | 40.0 kDa |
| Gene ID | 5004 |
|---|---|
| Gene Symbol | ORM1 |
| Other Names | AGP, Orosomucoid |
| Gene Source | Human |
| Source | Human Plasma |
| Assay&Purity | SDS-PAGE; ≥95% |
| Assay2&Purity2 | N/A; |
| Recombinant | No |
| Results | ≥ 120 units/mg protein. |
| Target/Specificity | Alpha 1 Acid Glycoprotein |
| Format | Lyophilized |
| Storage | -20°C; Lyophilized as a salt free solid. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Found in human plasma in concentrations of 55-140 mg per 100 ml. Classical standard glycoprotein for studies on the structure of the oligosaccharide units. Carbohydrate content is 40%. Its biological significance is unknown although it can bind progesterone 15 times as strongly as albumin. Sialic-acid-deficient alpha-1-AG has an affinity for vitamin B-12. Clinically, alpha 1 acid glycoprotein is an acute-phase reactant that together with haptoglobin is an indicator of acute inflammation. The alpha 1 acid glycoprotein: haptoglobin ratio is useful in studies of bone marrow disorders, hemolytic processes and metastases.
References
Dente L.,et al.EMBO J. 6:2289-2296(1987).
Board P.G.,et al.Gene 44:127-131(1986).
Dente L.,et al.Nucleic Acids Res. 13:3941-3952(1985).
Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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