FTO, mouse recombinant protein
Fat Mass and Obesity-associated Protein; FATSO.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8BGW1 |
---|---|
Concentration | 0.5 |
Calculated MW | ~55 kDa (SDS-PAGE). Mouse FTO (aa 2-502) is fused at the N-terminus to a His-tag. |
Gene ID | 26383 |
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Gene Symbol | FTO |
Other Names | Fat Mass and Obesity-associated Protein; FATSO. |
Gene Source | Mouse |
Source | E. coli |
Assay&Purity | SDS-PAGE; ≥90% |
Assay2&Purity2 | N/A; |
Recombinant | Yes |
Target/Specificity | FTO |
Format | Liquid |
Storage | -20°C; 0.5 mg/ml of 0.2 µm-filtered solution in 55 mM Tris-Cl, pH 8.2 containing 150 mM NaCl. |
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Provided below are standard protocols that you may find useful for product applications.
Background
FTO (Fat mass-and obesity-associated gene) is the responsible gene for mouse ‘fused toes’ mutation. An association between FTO genotype and type 2 diabetes has been confirmed. The presence of the FTO rs9939609 A-allele was found to be positively correlated with other symptoms of the metabolic syndrome, including higher fasting insulin, glucose, triglycerides, and lower HDL-cholesterol.
References
Peters T.,et al.Mamm. Genome 10:983-986(1999).
Okazaki N.,et al.DNA Res. 10:167-180(2003).
Carninci P.,et al.Science 309:1559-1563(2005).
Gerken T.,et al.Science 318:1469-1472(2007).
Jia G.,et al.FEBS Lett. 582:3313-3319(2008).
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