Calreticulin, human recombinant protein
CRP55; Calregulin; Endoplasmic Reticulum Resident Protein 60; ERp60; grp60
|Calculated MW||~55.0 kDa. Human calreticulin (aa 18-417) is fused at the C-terminus to a His-tag.|
|Other Names||CRP55; Calregulin; Endoplasmic Reticulum Resident Protein 60; ERp60; grp60|
|Storage||-20°C; 0.2 µm-filtered solution in 55 mM Tris-Cl, pH 8.2, containing 150 mM NaCl.|
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Calreticulin is involved in regulation of intracellular Ca2+ homoeostasis and ER Ca2+ capacity. It constitutes together with calnexin and ERp57 the ‘calreticulin/calnexin cycle’ that is responsible for folding and quality control of newly synthesized glycoproteins. Calreticulin has been implicated to play a role in many biological systems, including functions inside and outside the ER, indicating that the protein is a multi-process molecule. Recently, Calreticulin was shown to enhance the merger of macrophages and tumor cells, increasing phagocytosis.
McCauliffe D.P.,et al.J. Clin. Invest. 85:1379-1391(1990).
Rokeach L.A.,et al.J. Immunol. 147:3031-3039(1991).
McCauliffe D.P.,et al.J. Biol. Chem. 267:2557-2562(1992).
Liu J.,et al.Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
Goshima N.,et al.Nat. Methods 5:1011-1017(2008).
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