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Calreticulin, human recombinant protein

CRP55; Calregulin; Endoplasmic Reticulum Resident Protein 60; ERp60; grp60

     
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Product info
Primary Accession P27797
Calculated MW ~55.0 kDa. Human calreticulin (aa 18-417) is fused at the C-terminus to a His-tag.
Additional Info
Gene ID 811
Gene Symbol CALR
Other Names CRP55; Calregulin; Endoplasmic Reticulum Resident Protein 60; ERp60; grp60
Gene Source Human
Source E. coli
Assay&Purity SDS-PAGE; ≥90%
Assay2&Purity2 N/A;
Recombinant Yes
Target/Specificity Calreticulin
Format Liquid
Storage -20°C; 0.2 µm-filtered solution in 55 mM Tris-Cl, pH 8.2, containing 150 mM NaCl.
Citations (0)

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Background

Calreticulin is involved in regulation of intracellular Ca2+ homoeostasis and ER Ca2+ capacity. It constitutes together with calnexin and ERp57 the ‘calreticulin/calnexin cycle’ that is responsible for folding and quality control of newly synthesized glycoproteins. Calreticulin has been implicated to play a role in many biological systems, including functions inside and outside the ER, indicating that the protein is a multi-process molecule. Recently, Calreticulin was shown to enhance the merger of macrophages and tumor cells, increasing phagocytosis.

References

McCauliffe D.P.,et al.J. Clin. Invest. 85:1379-1391(1990).
Rokeach L.A.,et al.J. Immunol. 147:3031-3039(1991).
McCauliffe D.P.,et al.J. Biol. Chem. 267:2557-2562(1992).
Liu J.,et al.Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
Goshima N.,et al.Nat. Methods 5:1011-1017(2008).

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$ 275.00
$ 925.00
Cat# PBV11179r
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