Human CellExp UNC5B, human recombinant protein
Netrin Receptor UNC5B; UNC5H2; Protein Unc-5 Homolog 2; Protein Unc-5 Homolog B; p53-regulated Recep
|Calculated MW||~80.0 kDa. The extracellular region of human UNC5B (aa 28-363) is fused at the C-terminus to the Fc portion of human IgG1.|
|Other Names||Netrin Receptor UNC5B; UNC5H2; Protein Unc-5 Homolog 2; Protein Unc-5 Homolog B; p53-regulated Receptor for Death and Life Protein 1|
|Application Notes||Reconstitute with 50 µl sterile distilled water.|
|Storage||-20°C; Lyophilized in PBS.|
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Provided below are standard protocols that you may find useful for product applications.
UNC5B is a receptor for the netrin family of guidance molecules. It was identified as a mediator of the repulsive response in neurons and it is the only known netrin receptor with prominent endothelial expression. It has an important role in angiogenesis signaling.
Komatsuzaki K.,et al.Biochem. Biophys. Res. Commun. 297:898-905(2002).
Tanikawa C.,et al.Nat. Cell Biol. 5:216-223(2003).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Deloukas P.,et al.Nature 429:375-381(2004).
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