|Calculated MW||23.5 kDa (115-329 aa)|
|Other Names||CTSK, CTSO, CTSO3|
|Results||The specific activity is >5000 mU/mg (1U = 1 µmole/min/mg) as measured by Cathepsin K Activity Assay Kit|
|Storage||-80°C; 0.5 mg/ml solution in 25 mM Na2HPO4 and 500 mM NaCl (pH 7.0) with 50% glycerol.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Cathepsin K, a member of the papain cysteine proteinase family is the predominant proteinase responsible for the resorption of the bone matrix. Cathepsin cleaves proteins such as collagen type I, collagen type II and osteonectin, thereby playing a role in bone remodeling and resorption in osteoporosis, osteolytic bone metastasis and rheumatoid arthritis (Bromme and Okamoto, 1995; Drake, F. et al 1996; Bossard et al, 1996).
Shi G.-P.,et al.FEBS Lett. 357:129-134(1995).
Inaoka T.,et al.Biochem. Biophys. Res. Commun. 206:89-96(1995).
Li Y.,et al.J. Bone Miner. Res. 10:1197-1202(1995).
Broemme D.,et al.Biol. Chem. Hoppe-Seyler 376:379-384(1995).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.