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Cathepsin K, Active, human recombinant protein


Product info
Primary Accession P43235
Concentration 0.5
Calculated MW 23.5 kDa (115-329 aa)
Additional Info
Gene ID 1513
Gene Symbol CTSK
Other Names CTSK, CTSO, CTSO3
Gene Source Human
Source E. coli
Assay&Purity SDS-PAGE; ≥90%
Assay2&Purity2 N/A;
Recombinant Yes
Results The specific activity is >5000 mU/mg (1U = 1 µmole/min/mg) as measured by Cathepsin K Activity Assay Kit
Target/Specificity Cathepsin K
Format Liquid
Storage -80°C; 0.5 mg/ml solution in 25 mM Na2HPO4 and 500 mM NaCl (pH 7.0) with 50% glycerol.
Citations (0)

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Cathepsin K, a member of the papain cysteine proteinase family is the predominant proteinase responsible for the resorption of the bone matrix. Cathepsin cleaves proteins such as collagen type I, collagen type II and osteonectin, thereby playing a role in bone remodeling and resorption in osteoporosis, osteolytic bone metastasis and rheumatoid arthritis (Bromme and Okamoto, 1995; Drake, F. et al 1996; Bossard et al, 1996).


Shi G.-P.,et al.FEBS Lett. 357:129-134(1995).
Inaoka T.,et al.Biochem. Biophys. Res. Commun. 206:89-96(1995).
Li Y.,et al.J. Bone Miner. Res. 10:1197-1202(1995).
Broemme D.,et al.Biol. Chem. Hoppe-Seyler 376:379-384(1995).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.

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$ 285.00
$ 1,950.00
Cat# PBV11204r
(40 western blots)
Availability: 5-7days
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