|Calculated MW||44 kDa|
|Other Names||HDAC-8, HDACL1, Histone deacetylase 8|
|Source||Sf9 insect cells|
|Storage||-80°C; Liquid in 25 mM Tris, pH 7.5, 100 mM NaCl, 2.7 mM KCl, 3 mM MgCl2, 10 % glycerol.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Human Histone Deacetylase 8 (HDAC8) is a member of the class I Histone Deacetylases. HDACs are important enzymes for the transcriptional regulation of gene expression in eukaryotic cells. HDACs catalyze the removal of acetyl groups from lysines near the N-termini of histones. Human HDACs have been implicated in a variety of human diseases such as cardiomyopathy, osteodystrophy, neurodegenerative disorders, aging and cancer. Expression of HDAC8 is restricted to cells showing smooth muscle differentiation in normal human tissue and is a novel marker of smooth muscle differentiation. Like other class I and II HDAC members, the activity of HDAC8 is sensitive to HDAC inhibitor Trichostatin A (TSA).
Hu E.,et al.J. Biol. Chem. 275:15254-15264(2000).
Buggy J.J.,et al.Biochem. J. 350:199-205(2000).
Van den Wyngaert I.,et al.FEBS Lett. 478:77-83(2000).
McDonell N.,et al.Genomics 64:221-229(2000).
Bonaldo M.F.,et al.Genome Res. 6:791-806(1996).
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