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HDAC-8, human recombinant protein
HDAC-8,HDACL1, Histone deacetylase 8
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9BY41 |
|---|---|
| Calculated MW | 44 kDa |
| Gene ID | 55869 |
|---|---|
| Gene Symbol | HDAC8 |
| Other Names | HDAC-8, HDACL1, Histone deacetylase 8 |
| Gene Source | Human |
| Source | Sf9 insect cells |
| Assay&Purity | SDS-PAGE; ≥90% |
| Assay2&Purity2 | HPLC; |
| Recombinant | Yes |
| Format | Liquid |
| Storage | -80°C; Liquid in 25 mM Tris, pH 7.5, 100 mM NaCl, 2.7 mM KCl, 3 mM MgCl2, 10 % glycerol. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Human Histone Deacetylase 8 (HDAC8) is a member of the class I Histone Deacetylases. HDACs are important enzymes for the transcriptional regulation of gene expression in eukaryotic cells. HDACs catalyze the removal of acetyl groups from lysines near the N-termini of histones. Human HDACs have been implicated in a variety of human diseases such as cardiomyopathy, osteodystrophy, neurodegenerative disorders, aging and cancer. Expression of HDAC8 is restricted to cells showing smooth muscle differentiation in normal human tissue and is a novel marker of smooth muscle differentiation. Like other class I and II HDAC members, the activity of HDAC8 is sensitive to HDAC inhibitor Trichostatin A (TSA).
References
Hu E.,et al.J. Biol. Chem. 275:15254-15264(2000).
Buggy J.J.,et al.Biochem. J. 350:199-205(2000).
Van den Wyngaert I.,et al.FEBS Lett. 478:77-83(2000).
McDonell N.,et al.Genomics 64:221-229(2000).
Bonaldo M.F.,et al.Genome Res. 6:791-806(1996).
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