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DOT1L (2- 416 aa), Human recombinant protein

DOT1L (2- 416 aa), Human recombinant

Product info
Primary Accession Q8TEK3
Calculated MW 74.1 kDa (2- 416 aa + NT GST Tag)
Additional Info
Gene ID 84444
Gene Symbol DOT1L
Other Names Dot1-like; Disruptor of Telomeric Signaling 1-Like
Gene Source Human
Source E. coli
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 HPLC;
Recombinant Yes
Target/Specificity DOT1L
Format Liquid
Storage -80°C; 20 mM Tris, pH 8.0, containing 200 mM sodium chloride, 1 mM EDTA and 1 mM DTT.
Citations (0)

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Dot1L is a non-SET domain containing methyltransferase. It is the only enzyme known to methylate histone 3 at lysine 79, where it catalyzes mono-, di-, and trimethylation. Proper Dot1L function is necessary for transcriptional activation of many genes, DNA damage repair, and cell cycle regulation. Dot1L plays an essential role in MLL-rearranged leukemias and is being investigated as a drug-target for these leukemias. Experiments using siRNA or shRNA have shown that knockdown of Dot1L leads to loss of proliferation in lung cancer cells or faster reprogramming and increased yield of induced pluripotent stem cells, respectively. This protein product contains the methyltransferase domain of Dot1L.


Feng Q.,et al.Curr. Biol. 12:1052-1058(2002).
Grimwood J.,et al.Nature 428:529-535(2004).
Nagase T.,et al.DNA Res. 8:85-95(2001).
Jikuya H.,et al.DNA Res. 10:49-57(2003).
Okada Y.,et al.Cell 121:167-178(2005).

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$ 225.00
Cat# PBV11242r-25
Availability: 5-7days
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