RIZ1 (2-200 aa) (GST-tagged), Human recombinant protein
RIZ1 (2-200 aa) (GST-tagged), Human recombinant
|Calculated MW||49.5 kDa (2-200 aa + NT GST Tag)|
|Other Names||KMT8; PRDM2; PR Domain Zinc Finger Protein 2; Retinoblastoma Protein-interacting Zinc Finger Protein|
|Storage||-80°C; 50 mM Tris, pH 7.5, containing 150 mM sodium chloride and 20% glycerol.|
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Provided below are standard protocols that you may find useful for product applications.
Retinoblastoma protein-interacting zinc finger protein 1 (RIZ1), also known as PRDM2, is a SAM-dependent histone methyltransferase that specifically methylates histone H3 on lysine 9. RIZ1 contains 8 zinc-finger motifs and 1 PR domain. The RIZ gene encodes two different proteins, RIZ1 and RIZ2. RIZ1 is a tumor suppressor that can arrest the cell cycle and induce apoptosis. RIZ2 however, is a proto-oncoprotein lacking the N-terminal PR domain containing the methyltransferase activity. When RIZ1 is silenced or mutated, the reduced methyltransferase activity can lead to inheritable changes in chromatin methylation and gene expression patterns.
Buyse I.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 92:4467-4471(1995).
Liu L.,et al.J. Biol. Chem. 272:2984-2991(1997).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Gregory S.G.,et al.Nature 441:315-321(2006).
Shapiro V.S.,et al.Gene 163:329-330(1995).
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