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RIZ1 (2-200 aa) (GST-tagged), Human recombinant protein

RIZ1 (2-200 aa) (GST-tagged), Human recombinant

Product info
Primary Accession Q13029
Calculated MW 49.5 kDa (2-200 aa + NT GST Tag)
Additional Info
Gene ID 7799
Gene Symbol PRDM2
Other Names KMT8; PRDM2; PR Domain Zinc Finger Protein 2; Retinoblastoma Protein-interacting Zinc Finger Protein
Gene Source Human
Source E. coli
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 HPLC;
Recombinant Yes
Target/Specificity PRDM2
Format Liquid
Storage -80°C; 50 mM Tris, pH 7.5, containing 150 mM sodium chloride and 20% glycerol.
Citations (0)

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Retinoblastoma protein-interacting zinc finger protein 1 (RIZ1), also known as PRDM2, is a SAM-dependent histone methyltransferase that specifically methylates histone H3 on lysine 9. RIZ1 contains 8 zinc-finger motifs and 1 PR domain. The RIZ gene encodes two different proteins, RIZ1 and RIZ2. RIZ1 is a tumor suppressor that can arrest the cell cycle and induce apoptosis. RIZ2 however, is a proto-oncoprotein lacking the N-terminal PR domain containing the methyltransferase activity. When RIZ1 is silenced or mutated, the reduced methyltransferase activity can lead to inheritable changes in chromatin methylation and gene expression patterns.


Buyse I.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 92:4467-4471(1995).
Liu L.,et al.J. Biol. Chem. 272:2984-2991(1997).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Gregory S.G.,et al.Nature 441:315-321(2006).
Shapiro V.S.,et al.Gene 163:329-330(1995).

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$ 115.00
$ 215.00
Cat# PBV11248r-50
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