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Protein C, Human Plasma recombinant protein

Vitamin K-dependent protein C, Anticoagulant protein C, Autoprothrombin IIA, Blood coagulation facto

Product info
Primary Accession P04070
Calculated MW 62 kDa
Additional Info
Gene ID 5624
Gene Symbol PROC
Other Names Vitamin K-dependent protein C, Anticoagulant protein C, Autoprothrombin IIA, Blood coagulation factor XIV, PROC, PC, APC, PROC1, THPH3, THPH4.
Gene Source Human
Source Human Plasma
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 N/A;
Recombinant No
Target/Specificity Protein C
Format Liquid
Storage -80°C; In 20 mM Tris-HCl, 0.1 M NaCl, 1 mM Benzamidine -pH 7.4
Citations (0)

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Protein C (PROC) is a vitamin K-dependent serine protease which regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. PROC is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form, which contains a serine protease domain, functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in the PROC gene are linked with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis. This protein is purified from fresh frozen human plasma using a combination of salt precipitations and column chromatography.


Beckmann R.J.,et al.Nucleic Acids Res. 13:5233-5247(1985).
Foster D.C.,et al.Proc. Natl. Acad. Sci. U.S.A. 82:4673-4677(1985).
Plutzky J.,et al.Proc. Natl. Acad. Sci. U.S.A. 83:546-550(1986).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).

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$ 175.00
Cat# PBV11258r
(40 western blots)
Availability: 5-7days
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