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Activated Protein C, Human Plasma recombinant protein
Vitamin K-dependent protein C, Anticoagulant protein C, Autoprothrombin IIA, Blood coagulation facto
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P04070 |
|---|---|
| Calculated MW | 56 kDa |
| Gene ID | 5624 |
|---|---|
| Gene Symbol | PROC |
| Other Names | Vitamin K-dependent protein C, Anticoagulant protein C, Autoprothrombin IIA, Blood coagulation factor XIV, PROC, PC, APC, PROC1, THPH3, THPH4. |
| Gene Source | Human |
| Source | Human Plasma |
| Assay&Purity | SDS-PAGE; ≥95% |
| Assay2&Purity2 | N/A; |
| Recombinant | No |
| Results | Lot dependent |
| Target/Specificity | Activated Protein C |
| Format | Liquid |
| Storage | -80°C; In 20 mM Tris-HCl, 0.1 M NaCl, pH 7.4 |
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Provided below are standard protocols that you may find useful for product applications.
Background
The Activated Human Protein C was activated from homogeneous protein C by activation with purified alpha-thrombin. The alpha-thrombin is removed after activation. Complete activation is observed on SDS-PAGE. Protein C (PROC) is a vitamin K-dependent serine protease which regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. PROC is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form, which contains a serine protease domain, functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in the PROC gene are linked with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis. This protein is purified from fresh frozen human plasma using a combination of salt precipitations and column chromatography.
References
Beckmann R.J.,et al.Nucleic Acids Res. 13:5233-5247(1985).
Foster D.C.,et al.Proc. Natl. Acad. Sci. U.S.A. 82:4673-4677(1985).
Plutzky J.,et al.Proc. Natl. Acad. Sci. U.S.A. 83:546-550(1986).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
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