Factor VII, Human Plasma recombinant protein
Proconvertin, Serum prothrombin conversion accelerator.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P08709 |
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Calculated MW | 50 kDa |
Gene ID | 2155 |
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Gene Symbol | F7 |
Other Names | Proconvertin, Serum prothrombin conversion accelerator. |
Gene Source | Human |
Source | Human Plasma |
Assay&Purity | SDS-PAGE; ≥95% |
Assay2&Purity2 | N/A; |
Recombinant | No |
Results | Lot dependent |
Target/Specificity | Factor VII |
Format | Liquid |
Storage | -80°C; In 20 mM Tris-HCl, 0.1 M NaCl, 1 mM Benzamidine, pH 7.4. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Human factor VII is a single chain, vitamin K-dependent, plasma glycoprotein which is synthesized in the liver. Prior to secretion into the blood, post translational modification by a vitamin K-dependent carboxylase produces ten-carboxyglutamic acid (gla) residues located in the NH2-terminal portion of the molecule, which facilitate cell membrane binding. Factor VII is proteolytically activated to the serine protease, factor VIIa, during coagulation. Factor VII can be activated by thrombin, factor IXa, factor Xa or factor XIIa.
References
Hagen F.S.,et al.Proc. Natl. Acad. Sci. U.S.A. 83:2412-2416(1986).
O'Hara P.J.,et al.Proc. Natl. Acad. Sci. U.S.A. 84:5158-5162(1987).
Sabater-Lleal M.,et al.Hum. Genet. 118:741-751(2006).
Soria J.M.,et al.Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
Masroori N.,et al.Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
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