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>   home   >   Products   >   Proteins   >   Factor VII, Human Plasma recombinant protein   

Factor VII, Human Plasma recombinant protein

Proconvertin, Serum prothrombin conversion accelerator.

     
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Product info
Primary Accession P08709
Calculated MW 50 kDa
Additional Info
Gene ID 2155
Gene Symbol F7
Other Names Proconvertin, Serum prothrombin conversion accelerator.
Gene Source Human
Source Human Plasma
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 N/A;
Recombinant No
Results Lot dependent
Target/Specificity Factor VII
Format Liquid
Storage -80°C; In 20 mM Tris-HCl, 0.1 M NaCl, 1 mM Benzamidine, pH 7.4.
Citations (0)

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Background

Human factor VII is a single chain, vitamin K-dependent, plasma glycoprotein which is synthesized in the liver. Prior to secretion into the blood, post translational modification by a vitamin K-dependent carboxylase produces ten-carboxyglutamic acid (gla) residues located in the NH2-terminal portion of the molecule, which facilitate cell membrane binding. Factor VII is proteolytically activated to the serine protease, factor VIIa, during coagulation. Factor VII can be activated by thrombin, factor IXa, factor Xa or factor XIIa.

References

Hagen F.S.,et al.Proc. Natl. Acad. Sci. U.S.A. 83:2412-2416(1986).
O'Hara P.J.,et al.Proc. Natl. Acad. Sci. U.S.A. 84:5158-5162(1987).
Sabater-Lleal M.,et al.Hum. Genet. 118:741-751(2006).
Soria J.M.,et al.Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
Masroori N.,et al.Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.

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$ 175.00
Cat# PBV11262r-50
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