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Pro-Urokinase, human recombinant protein

Single chain Urokinase-type plasminogen activator (scuPA), Urokinase-type Plasminogen Activator uPA,

Product info
Primary Accession P00749
Calculated MW 49.3 kDa
Additional Info
Gene ID 5328
Gene Symbol PLAU
Other Names Single chain Urokinase-type plasminogen activator (scuPA), Urokinase-type Plasminogen Activator uPA, PLAU.
Gene Source Human
Source E.coli
Assay&Purity SDS-PAGE; ≥90%
Assay2&Purity2 HPLC;
Recombinant Yes
Results >1200 mU/mg (1 U = Digestion of 1 µmole of Z-GGR-AMC substrate in 1 min at 37ºC.)
Target/Specificity Pro-Urokinase
Application Notes Briefly spin down the vial and reconstitute in water to 0.5-1 mg/ml and store at –80°C.
Format Lyophilized powder
Storage -20°C; Lyophilized from proprietary buffer.
Citations (0)

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Urokinase or Urokinase-type plasminogen activator (uPA) is a serine protease (EC It is secreted as a single-chain zymogen, pro-Urokinase, possessing little or no intrinsic enzymatic activity. The single chain zymogen is converted into the active two chain enzyme (tcuPA) by cleavage of the bond between Lys157 and Ile158. After activation, Urokinase specifically cleaves the proenzyme plasminogen to form the active enzyme plasmin. The active plasmin then catalyzes the breakdown of fibrin polymers of blood clots. Urokinase is involved in a number of biological functions including fibrinolysis, embryogenesis, cell migration, tissue remodeling, ovulation, and wound healing. Additionally, it is a potent marker of invasion and metastasis in a variety of human cancers associated with breast, stomach, colon, bladder, ovary, brain and endometrium.


Holmes W.E.,et al.Biotechnology (N.Y.) 3:923-929(1985).
Jacobs P.,et al.DNA 4:139-146(1985).
Nagai M.,et al.Gene 36:183-188(1985).
Riccio A.,et al.Nucleic Acids Res. 13:2759-2771(1985).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.

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$ 140.00
$ 395.00
$ 1,495.00
Cat# PBV11271r-10
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