|Calculated MW||85.0 kDa|
|Gene Symbol||Lyn B|
|Other Names||Lyn B|
|Source||Baculovirus (Sf9 insect cells)|
|Storage||-80°C; Recombinant proteins in storage buffer (50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol).|
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Provided below are standard protocols that you may find useful for product applications.
Lyn is a 56 kd tyrosine kinase that is similar to mouse T-lymphocyte-specific tyrosine kinase p56lck and the v-yes protein as well as to the gene products of v-fgr and v-src. Northern hybridization analysis showed that a 3.2-kilobase Lyn mRNA was expressed in a variety of tissues of the human fetus (1). Lyn is expressed preferentially in B cells and can be coimmunoprecipitated with IgM suggesting that Lyn is physically associated with membrane-bound IgM, and participates in antigen-mediated signal transduction (2). Crosslinking of membrane-bound IgM with antibody induces rapid increase in activities of Lyn and Lyn-associated phosphatidylinositol 3-kinase (3). Crosslinking of B-cell antigen receptor also induces association of Lyn with an 85-kDa noncatalytic subunit of phosphatidylinositol 3-kinase. Thus, Lyn is functionally associated with membrane-bound IgM and participates in B-cell antigen receptor-mediated signaling.
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