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BLK, Active recombinant protein

BLK, B lymphocyte kinase

Product info
Primary Accession P51451
Concentration 0.1
Calculated MW 84.0 kDa
Additional Info
Gene ID 640
Gene Symbol BLK
Other Names BLK, B lymphocyte kinase, p55-Blk
Source Baculovirus (Sf9 insect cells)
Assay&Purity SDS-PAGE; ≥90%
Assay2&Purity2 HPLC;
Recombinant Yes
Format Liquid
Storage -80°C; Recombinant protein in storage buffer (50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol).
Citations (0)

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Blk, also known as B lymphoid kinase, is a 55 kd tyrosine kinases with a SH3, SH2 and catalytic domains that contain consensus sequences of the src protein tyrosine kinase family. Blk is expressed specifically in the B cell lineage and plays a role in signal transduction pathway that is restricted to B lymphoid cells (1). Stimulation of resting B-lymphocytes with antibodies to surface immunoglobulin (sIgD or sIgM) induces activation of Blk (2). Upon activation, the SH2 domain of Blk binds more than 10 distinct phosphoprotein including those of 72, 76, 115, and 130 kd (3). Blk prefers peptide substrates of the structure I/L-Y-D/E-X-L which resemble critical features of the ITAM motifs found in, e.g. the intracellular components Ig-α and Ig-β of the β cell receptor. Blk has a strong preference for a negatively charged amino acid in position +1 (4).


Islam K.B.,et al.J. Immunol. 154:1265-1272(1995).
Drebin J.A.,et al.Oncogene 10:477-486(1995).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Donovan J.A.,et al.J. Biol. Chem. 269:22921-22924(1994).

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$ 295.00
Cat# PBV11299r
(40 western blots)
Availability: 5-7days
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