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Pro-MMP-8, human recombinant protein

Matrix metalloproteinase-13

     
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Product info
Primary Accession P22894
Concentration >100 mUnits/mg
Calculated MW 40/42 kDa
Additional Info
Gene ID 4317
Gene Symbol MMP8
Other Names Neutrophil collagenase (EC 3.4.24.34) (Matrix metalloproteinase-8) (MMP-8) (PMNL collagenase) (PMNL-CL)
Gene Source Human
Source Human neutrophil granulocytes (Buffy Coat)
Assay&Purity SDS-PAGE;
Assay2&Purity2 HPLC;
Recombinant No
Format Liquid
Storage -80°C; In 50 mM Tris-HCl, pH 7; 200 mM NaCl; 5 mM CaCl₂; 1 µM ZnCl₂; 0.05% Brij 35; 0,05% NaN₃
Citations (0)

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Background

Human neutrophil collagenase (HNC) has been purified from extracts of fresh and outdated buffy coats and from exudates of phorbol myristate acetate-stimulated neutrophils. The MMP-8 present in the starting material can either be latent or active, or have an app. relative molecular mass of 75-kDa and/or 58-kDa. The rather complex pattern of activation of the latent 58-kDa and 75-kDa species by trypsin, organomercurials and oxidants has been investigated. MMP-8 was shown to preferentially hydrolyze type I over type II, and type III collagens in solution and to be a glycoprotein that contains complex N-linked oligosaccharides leading to multiple forms of MMP-8 in SDS-PAGE. The action of endoglycosidase on the latent 58-kDa form produces 42/40-kDa species (Gao et al. 1992, Mallya et al. 1990). This indicates that MMP-8 is an N-linked, complex glycoprotein that appears to be glycosylated at multiple sites.

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$ 195.00
Cat# PBV11353r
Size:
Quantity:
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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