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TIMP-2, human fibroblasts recombinant protein

Tissue Inhibitor of Matrix Metalloproteinases – 2

     
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Product info
Primary Accession P16035
Concentration 0.1
Calculated MW 21.0 kDa
Additional Info
Gene ID 7077
Gene Symbol TIMP2
Other Names Metalloproteinase inhibitor 2 (CSC-21K) (Tissue inhibitor of metalloproteinases 2) (TIMP-2)
Gene Source Human
Source Isolated from human fibroblasts
Assay&Purity SDS-PAGE; ≥90%
Assay2&Purity2 HPLC;
Recombinant No
Format Liquid
Storage -80°C; In 50 mM Tris-HCl, pH 7; 200 mM NaCl; 5 mM CaCl₂; 1 µM ZnCl₂; 0.05% Brij 35; 0,05% NaN₃
Citations (0)

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Background

Glycoprotein that belongs to a family which takes part in the activation and regulation of the MMP-activity. Forms a non-covalent stoichiometric complex with latent and active MMP's. Inhibits the activities of MMP-1, MMP-2, MMP-12 and transin.

References

Stetler-Stevenson W.G.,et al.J. Biol. Chem. 265:13933-13938(1990).
Boone T.C.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:2800-2804(1990).
Hammani K.,et al.J. Biol. Chem. 271:25498-25505(1996).
Malik K.,et al.Submitted (AUG-1990) to the EMBL/GenBank/DDBJ databases.
Stetler-Stevenson W.G.,et al.J. Biol. Chem. 264:17374-17378(1989).

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$ 265.00
Cat# PBV11357r-5
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