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DUSP23, human recombinant protein
Dual specificity protein phosphatase 23, DUSP25, LDP-3, MOSP, VHZ
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9BVJ7 |
|---|---|
| Concentration | 1 |
| Calculated MW | 18.8 kDa (170 aa, 1-150 aa + His Tag) |
| Gene ID | 54935 |
|---|---|
| Gene Symbol | DUSP23 |
| Other Names | Dual specificity protein phosphatase 23, DUSP25, LDP-3, MOSP, VHZ |
| Gene Source | Human |
| Source | E.coli |
| Assay&Purity | SDS-PAGE; ≥90% |
| Assay2&Purity2 | N/A; |
| Recombinant | Yes |
| Results | Specific activity is > 320 unit/mg |
| Sequence | MGSSHHHHHH SSGLVPRGSH MGVQPPNFSW VLPGRLAGLA LPRLPAHYQF LLDLGVRHLV SLTERGPPHS DSCPGLTLHR LRIPDFCPPA PDQIDRFVQI VDEANARGEA VGVHCALGFG RTGTMLACYL VKERGLAAGD AIAEIRRLRP GSIETYEQEK AVFQFYQRTK |
| Target/Specificity | DUSP23 |
| Format | Liquid |
| Storage | -20°C; 1 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 100 mM NaCl and 2 mM DTT |
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Provided below are standard protocols that you may find useful for product applications.
Background
DuSP23, also known as low molecular mass dual specificity phosphatase 3(LDP-3), belongs to the protein-tyrosine phosphatase family. This protein is a protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. This protein able to enhance activation of JNK and p38(MAPK14). Recombinant human DuSP23 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
References
Takagaki K.,et al.Biochem. J. 383:447-455(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Alonso A.,et al.J. Biol. Chem. 279:35768-35774(2004).
Wu Q.,et al.Int. J. Biochem. Cell Biol. 36:1542-1553(2004).
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