|Calculated MW||18.8 kDa (170 aa, 1-150 aa + His Tag)|
|Other Names||Dual specificity protein phosphatase 23, DUSP25, LDP-3, MOSP, VHZ|
|Results||Specific activity is > 320 unit/mg|
|Sequence||MGSSHHHHHH SSGLVPRGSH MGVQPPNFSW VLPGRLAGLA LPRLPAHYQF LLDLGVRHLV SLTERGPPHS DSCPGLTLHR LRIPDFCPPA PDQIDRFVQI VDEANARGEA VGVHCALGFG RTGTMLACYL VKERGLAAGD AIAEIRRLRP GSIETYEQEK AVFQFYQRTK|
|Storage||-20°C; 1 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 100 mM NaCl and 2 mM DTT|
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Provided below are standard protocols that you may find useful for product applications.
DuSP23, also known as low molecular mass dual specificity phosphatase 3(LDP-3), belongs to the protein-tyrosine phosphatase family. This protein is a protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. This protein able to enhance activation of JNK and p38(MAPK14). Recombinant human DuSP23 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Takagaki K.,et al.Biochem. J. 383:447-455(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Alonso A.,et al.J. Biol. Chem. 279:35768-35774(2004).
Wu Q.,et al.Int. J. Biochem. Cell Biol. 36:1542-1553(2004).
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