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>   home   >   Products   >   Proteins   >   HMG-CoA Reductase Catalytic Domain (GST Tagged), human recombinant protein   

HMG-CoA Reductase Catalytic Domain (GST Tagged), human recombinant protein

3-Hydroxy-3-methylglutaryl-CoA reductase, HMGR, HMGCR

Product info
Primary Accession P04035
Calculated MW 75.9 kDa (426–888 aa, NT GST Tag)
Additional Info
Gene ID 3156
Gene Symbol HMGCR
Other Names 3-Hydroxy-3-methylglutaryl-CoA reductase, HMGR, HMGCR
Gene Source Human
Source E. coli
Assay&Purity SDS-PAGE; ≥90%
Assay2&Purity2 N/A;
Recombinant Yes
Results > 1.0 Unit/mg
Sequence 426–888 aa
Target/Specificity HMG-CoA Reductase
Application Notes Briefly spin down the vial and reconstitute in 50% glycerol in PBS to 0.5-1.0 mg/ml and store at –80°C.
Format Lyophilized
Storage -80°C; Lyophilized from proprietary buffer containing BSA
Citations (0)

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HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-CoA reductase or HMGR) (EC is a transmembrane protein involved in the mevalonate pathway, the metabolic pathway that produces cholesterol from acetyl-CoA. In an NADPH-dependent reaction, HMG-CoA reductase reduces HMG-CoA to generate mevalonate and CoA. Since HMG-CoA reductase catalyzes the rate limiting step in cholesterol synthesis, it is a primary target of a group of cholesterol-lowering drugs known as statins. Inhibition of HMG-CoA reductase induces expression of LDL receptors in the liver, which lowers plasma concentration of cholesterol.


Luskey K.L.,et al.J. Biol. Chem. 260:10271-10277(1985).
Nakajima T.,et al.Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
Rieder M.J.,et al.Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Schmutz J.,et al.Nature 431:268-274(2004).

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$ 85.00
$ 325.00
Cat# PBV11400r
(40 western blots)
Availability: 5-7days
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