HMG-CoA Reductase Catalytic Domain (GST Tagged), human recombinant protein
3-Hydroxy-3-methylglutaryl-CoA reductase, HMGR, HMGCR
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P04035 |
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Calculated MW | 75.9 kDa (426–888 aa, NT GST Tag) |
Gene ID | 3156 |
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Gene Symbol | HMGCR |
Other Names | 3-Hydroxy-3-methylglutaryl-CoA reductase, HMGR, HMGCR |
Gene Source | Human |
Source | E. coli |
Assay&Purity | SDS-PAGE; ≥90% |
Assay2&Purity2 | N/A; |
Recombinant | Yes |
Results | > 1.0 Unit/mg |
Sequence | 426–888 aa |
Target/Specificity | HMG-CoA Reductase |
Application Notes | Briefly spin down the vial and reconstitute in 50% glycerol in PBS to 0.5-1.0 mg/ml and store at –80°C. |
Format | Lyophilized |
Storage | -80°C; Lyophilized from proprietary buffer containing BSA |
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Provided below are standard protocols that you may find useful for product applications.
Background
HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-CoA reductase or HMGR) (EC 1.1.1.34) is a transmembrane protein involved in the mevalonate pathway, the metabolic pathway that produces cholesterol from acetyl-CoA. In an NADPH-dependent reaction, HMG-CoA reductase reduces HMG-CoA to generate mevalonate and CoA. Since HMG-CoA reductase catalyzes the rate limiting step in cholesterol synthesis, it is a primary target of a group of cholesterol-lowering drugs known as statins. Inhibition of HMG-CoA reductase induces expression of LDL receptors in the liver, which lowers plasma concentration of cholesterol.
References
Luskey K.L.,et al.J. Biol. Chem. 260:10271-10277(1985).
Nakajima T.,et al.Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
Rieder M.J.,et al.Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Schmutz J.,et al.Nature 431:268-274(2004).
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