HMG-CoA Reductase Catalytic Domain (GST Tagged), human recombinant protein
3-Hydroxy-3-methylglutaryl-CoA reductase, HMGR, HMGCR
|Calculated MW||75.9 kDa (426–888 aa, NT GST Tag)|
|Other Names||3-Hydroxy-3-methylglutaryl-CoA reductase, HMGR, HMGCR|
|Results||> 1.0 Unit/mg|
|Application Notes||Briefly spin down the vial and reconstitute in 50% glycerol in PBS to 0.5-1.0 mg/ml and store at –80°C.|
|Storage||-80°C; Lyophilized from proprietary buffer containing BSA|
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Provided below are standard protocols that you may find useful for product applications.
HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-CoA reductase or HMGR) (EC 220.127.116.11) is a transmembrane protein involved in the mevalonate pathway, the metabolic pathway that produces cholesterol from acetyl-CoA. In an NADPH-dependent reaction, HMG-CoA reductase reduces HMG-CoA to generate mevalonate and CoA. Since HMG-CoA reductase catalyzes the rate limiting step in cholesterol synthesis, it is a primary target of a group of cholesterol-lowering drugs known as statins. Inhibition of HMG-CoA reductase induces expression of LDL receptors in the liver, which lowers plasma concentration of cholesterol.
Luskey K.L.,et al.J. Biol. Chem. 260:10271-10277(1985).
Nakajima T.,et al.Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
Rieder M.J.,et al.Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Schmutz J.,et al.Nature 431:268-274(2004).
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