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L-Methionine γ-Lyase, Pseudomonas putida recombinant protein

L-Methionine-α-deamino-γ-mercaptomethane-Lyase, Methioninase, METase, MGL, mdeA

     
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Product info
Primary Accession P13254
Calculated MW 47.1 kDa (1-398 aa, NT Poly-His Tag)
Additional Info
Gene Symbol mdeA
Other Names L-Methionine-α-deamino-γ-mercaptomethane-Lyase, Methioninase, METase, MGL, mdeA
Gene Source Pseudomonas putida
Source E. coli
Assay&Purity SDS-PAGE; ≥90%
Assay2&Purity2 HPLC;
Recombinant Yes
Results ≥ 0.5 U/mg.
Sequence 1-398 aa, NT Poly-His Tag
Target/Specificity L-Methionine γ-Lyase
Application Notes Briefly spin down and reconstitute in water or phosphate buffer.
Format Lyophilized
Storage –20°C; Lyophilized from 10 mg/ml in 20 mM potassium phosphate, 150 mM NaCl, pH 8.3.
Citations (0)

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Background

Methionine gamma-lyase (EC 4.4.1.11) from Pseudomonas putida is a PLP-dependent enzyme which plays a central role in sulfur amino acid metabolism. METase catalyzes the α, γ-elimination of methionine to α-ketobutyrate, methanethiol, and ammonia. METase also catalyzes the α, γ-elimination of other sulfur containing amino acids, such as homocysteine, cysteine. Because of its ability to deplete methionine, METase has been considered as a viable component of cancer therapeutics against methionine-dependent tumor cells. METase has also been utilized to design drug targets for the infectious diseases caused by parasitic protozoa and anaerobic periodontal bacteria.

References

Inoue H.,et al.J. Biochem. 117:1120-1125(1995).
Inoue H.,et al.J. Bacteriol. 179:3956-3962(1997).
Nakayama T.,et al.Biochemistry 27:1587-1591(1988).

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$ 95.00
$ 295.00
Cat# PBV11407r
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