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Cytochrome P450 2D6, human recombinant protein
Cytochrome P450 2D6, CYPIID6, P450-DB1, Debrisoquine 4-hydroxylase, CYP2D6, CPD6, CYP2D, CYP2DL1, P4
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P10635 |
|---|---|
| Concentration | Lot specific |
| Calculated MW | 55 kDa |
| Gene ID | 1565 |
|---|---|
| Gene Symbol | CYP2D6 |
| Other Names | Cytochrome P450 2D6, CYPIID6, P450-DB1, Debrisoquine 4-hydroxylase, CYP2D6, CPD6, CYP2D, CYP2DL1, P450C2D, MGC120389, MGC120390, LKM1, liver/kidney microsomal antigen 1 |
| Gene Source | Human |
| Source | Sf9 Insect cells |
| Assay&Purity | SDS-PAGE; Glycosylated, so purity ≥40% |
| Assay2&Purity2 | N/A; |
| Recombinant | Yes |
| Target/Specificity | Cytochrome P450 2D6 |
| Application Notes | In 50 mM Potassium phosphate buffer pH 7.5, 15% glycerol, 1 mM DTT and 1% Triton X-100 |
| Format | Liquid |
| Storage | -20°C; Sterile filtered, 50 mM Potassium phosphate buffer pH 7.5, 15% glycerol, 1 mM DTT and 1% Triton X-100 |
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Provided below are standard protocols that you may find useful for product applications.
Background
Cytochrome P450 2D6 is a member of a family of microsomal enzymes (mono-oxygenases) present in the endoplasmic reticulum membrane, which detoxify xenobiotic compounds. Cytochrome P450 2D6 is the molecular target of autoantibodies against the "liver kidney microsomal antigen 1" (LKM 1) which has been classically studied by immunofluorescence microscopy. The presence of these autoantibodies is considered indicative of Autoimmune Hepatitis Type 2; LKM 1 antibodies have also been detected in patients with hepatitis C viral infection. The use of a purified recombinant Cytochrome P450 2D6 antigen allows the differentiation of autoimmune hepatitis from drug-induced hepatitis where transient autoantibodies to other P450 family members occur which cannot be differentiated by immunofluorescence techniques.
References
Gonzalez F.J.,et al.Genomics 2:174-179(1988).
Gonzalez F.J.,et al.Nature 331:442-446(1988).
Kimura S.,et al.Am. J. Hum. Genet. 45:889-904(1989).
Gaedigk A.,et al.Pharmacogenomics J. 5:173-182(2005).
Gaedigk A.,et al.Pharmacogenomics J. 5:276-276(2005).
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