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Cytochrome P450 2D6, human recombinant protein

Cytochrome P450 2D6, CYPIID6, P450-DB1, Debrisoquine 4-hydroxylase, CYP2D6, CPD6, CYP2D, CYP2DL1, P4

Product info
Primary Accession P10635
Concentration Lot specific
Calculated MW 55 kDa
Additional Info
Gene ID 1565
Gene Symbol CYP2D6
Other Names Cytochrome P450 2D6, CYPIID6, P450-DB1, Debrisoquine 4-hydroxylase, CYP2D6, CPD6, CYP2D, CYP2DL1, P450C2D, MGC120389, MGC120390, LKM1, liver/kidney microsomal antigen 1
Gene Source Human
Source Sf9 Insect cells
Assay&Purity SDS-PAGE; Glycosylated, so purity ≥40%
Assay2&Purity2 N/A;
Recombinant Yes
Target/Specificity Cytochrome P450 2D6
Application Notes In 50 mM Potassium phosphate buffer pH 7.5, 15% glycerol, 1 mM DTT and 1% Triton X-100
Format Liquid
Storage -20°C; Sterile filtered, 50 mM Potassium phosphate buffer pH 7.5, 15% glycerol, 1 mM DTT and 1% Triton X-100
Citations (0)

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Cytochrome P450 2D6 is a member of a family of microsomal enzymes (mono-oxygenases) present in the endoplasmic reticulum membrane, which detoxify xenobiotic compounds. Cytochrome P450 2D6 is the molecular target of autoantibodies against the "liver kidney microsomal antigen 1" (LKM 1) which has been classically studied by immunofluorescence microscopy. The presence of these autoantibodies is considered indicative of Autoimmune Hepatitis Type 2; LKM 1 antibodies have also been detected in patients with hepatitis C viral infection. The use of a purified recombinant Cytochrome P450 2D6 antigen allows the differentiation of autoimmune hepatitis from drug-induced hepatitis where transient autoantibodies to other P450 family members occur which cannot be differentiated by immunofluorescence techniques.


Gonzalez F.J.,et al.Genomics 2:174-179(1988).
Gonzalez F.J.,et al.Nature 331:442-446(1988).
Kimura S.,et al.Am. J. Hum. Genet. 45:889-904(1989).
Gaedigk A.,et al.Pharmacogenomics J. 5:173-182(2005).
Gaedigk A.,et al.Pharmacogenomics J. 5:276-276(2005).

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Cat# PBV11415r-5
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