|Calculated MW||34277 Da|
|Gene ID||CASP2- 835 CASP3- 836 CASP7- 840|
|Gene Symbol||CASP2 CASP3 CASP7|
|Application Notes||Reconstitute to 1 unit per µl in PBS.|
|Storage||-70°C; Lyophilized powder|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Caspase family consists of more than 10 members. Based on their extended substrate specificities, these enzymes were divided into three major groups: Group I (contains caspase-1,-4,-5), Group II (contains caspase-2,-3,-7), and Group III (contains caspase-6,-8,-9,-10). Evidences have suggested that Group I caspases are involved primarily in the production of inflammatory cytokines, while group II and III enzymes function in apoptosis as effectors and upstream activators, respectively. The group caspases were expressed in E. coli and routinely tested for their ability to enzymatically cleave the substrate VDVAD-pNA (for caspase-2) and DEVD-pNA (for caspase-3 & -7).
Fernandes-Alnemri T.,et al.Cancer Res. 55:6045-6052(1995).
Duan H.,et al.J. Biol. Chem. 271:1621-1625(1996).
Lippke J.A.,et al.J. Biol. Chem. 271:1825-1828(1996).
Juan T.S.-C.,et al.Genomics 40:86-93(1997).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
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