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>   home   >   Products   >   Proteins   >   Active D-2-Hydroxyglutaratate Dehydrogenase (D2HGDH), Recombinant   

Active D-2-Hydroxyglutaratate Dehydrogenase (D2HGDH), Recombinant

D-2-hydroxyglutarate dehydrogenase, D2HGDH, D2HGD

     
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Product info
Primary Accession N/A
Calculated MW 39 kDa
Additional Info
Other Names D-2-hydroxyglutarate dehydrogenase, D2HGDH, D2HGD
Gene Source Acidaminococcus fermentans
Source E. coli
Assay&Purity SDS-PAGE;≥99%
Recombinant Yes
Sequence Full-length his-tagged D2HGDH
Target/Specificity D2HGDH
Application Notes Reconstitute in water to a concentration of 0.1-5 mg/ml. The solution can be diluted into other aqueous buffers and stored at –20°C for future use.
Format Dry powder
Storage -20°C;Lyophilized powder
Citations (0)

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Background

D-2-hydroxyglutarate (D2HG) level is significantly increased in metabolic diseases and various cancers such as acute myeloid leukemia. Studies suggest that the detection of D2HG serves as a biomarker assay related to IDH (isocitrate dehydrogenase) mutations. D2HGDH is a special NAD-dependent enzyme which reacts with D2HG specifically and converts D2HG to α-ketoglutarate. D2HGDH is a key enzyme to distinguish between two metabolites, D2HG and L-2-hydroxyglutarate (L2HG), during biomarker assays.

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$ 285.00
$ 1,140.00
Cat# PBV11456r-50
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