Human CellExp™ Biotinylated Fc gamma RI/CD64, human recombinant
High affinity immunoglobulin gamma Fc receptor I, IgG Fc receptor I, Fc-gamma RI, FcRI, Fc-gamma RIA
|Calculated MW||The protein has a calculated MW of 34.3 kDa. The reducing (R) protein migrates as 45-60 kDa in SDS-PAGE due to glycosylation.|
|Other Names||High affinity immunoglobulin gamma Fc receptor I, IgG Fc receptor I, Fc-gamma RI, FcRI, Fc-gamma RIA, FcgammaRIa, CD64 , FCGR1A|
|Source||HEK 293 cells|
|Sequence||Gln 16 – Pro 288|
|Target/Specificity||Fc gamma RI|
|Application Notes||Reconstitute in sterile deionized water to a stock solution of 200 µg/mL. Solubilize for 30 to 60 minutes at room temperature with occasional gentle mixing. Carrier protein (0.1% (W/V) HSA or BSA) is recommended for further dilution and long term storage.|
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Provided below are standard protocols that you may find useful for product applications.
Receptors that recognize the Fc portion of IgG are divided into three groups designated Fc gamma RI, RII, and RIII, also known respectively as CD64, CD32, and CD16. Fc gamma RI binds IgG with high affinity and functions during early immune responses. Fc gamma RII and RIII are low affinity receptors that recognize IgG as aggregates surrounding multivalent antigens during late immune responses.
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