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CSTB, human recombinant
Cystatin-B, Stefin B, PME, CST6
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | NP_000091 |
|---|---|
| Concentration | 1 mg/ml |
| Calculated MW | This protein is fused with a 6× His tag at N-terminus and has a calculated MW of 13 kDa. |
| Other Names | Cystatin-B, Stefin B, PME, CST6 |
|---|---|
| Gene Source | Human |
| Source | E.coli |
| Assay&Purity | SDS-PAGE;>95% |
| Assay2&Purity2 | N/A;>95% |
| Recombinant | Yes |
| Sequence | MGSSHHHHHH SSGLVPRGSH MMCGAPSATQ PATAETQHIA DQVRSQLEEK ENKKFPVFKA VSFKSQVVAG TNYFIKVHVG DEDFVHLRVF QSLPHENKPL TLSNYQTNKA KHDELTYF |
| Target/Specificity | CSTB |
| Application Notes | In 20 mM Tris-HCl buffer (pH8.0) containing 50mM NaCl. |
| Format | Liquid |
| Storage | -20°C;Liquid |
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Provided below are standard protocols that you may find useful for product applications.
Background
CSTB, also known as Cystatin B is an anti-protease implicated in myoclonus epilepsy, a degenerative disease of the central nervous system. The cystatin superfamily encompasses proteins that contain multiple cystatin like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. This protein is able to form a dimer stabilized by noncovalent forces and is thought to play a role in protecting against the proteases leaking from lysosomes. In cells, CSTB is located in the lysosomes and the cytoplasm, but also in the nucleus.
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