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Human CellExp™ CD19, Human recombinant

CD19, B4, CVID3, MGC12802

     
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Product info
Primary Accession AAH06338
Calculated MW This protein is fused with a 6× His tag at N-terminus and has a calculated MW of 31.6 kDa.
Additional Info
Other Names CD19, B4, CVID3, MGC12802
Gene Source Human
Source HEK 293 cells
Assay&Purity SDS-PAGE;>95%
Assay2&Purity2 N/A;>95%
Recombinant Yes
Target/Specificity CD19
Application Notes Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml
Format Lyophilized
Storage -20°C;Lyophilized
Citations (0)

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Background

B-lymphocyte antigen CD19 is also known as CD19 (Cluster of Differentiation 19), is a single-pass type I membrane protein which contains two Ig-like C2-type (immunoglobulin-like) domains. CD19 is expressed on follicular dendritic cells and B cells. In fact, it is present on B cells from earliest recognizable B-lineage cells during development to B-cell blasts but is lost on maturation to plasma cells. It primarily acts as a B cell co-receptor in conjunction with CD21 and CD81. Upon activation, the cytoplasmic tail of CD19 becomes phosphorylated, which leads to binding by Src-family kinases and recruitment of PI-3 kinase. As on T cells, several surface molecules form the antigen receptor and form a complex on B lymphocytes. The (almost) B cell-specific CD19 phosphoglycoprotein is one of these molecules. The others are CD21 and CD81. These surface immunoglobulin (sIg)-associated molecules facilitate signal transduction. On living B cells, anti-immunoglobulin antibody mimicking exogenous antigen causes CD19 to bind to sIg and internalize with it. The reverse process has not been demonstrated, suggesting that formation of this receptor complex is antigen-induced. This molecular association has been confirmed by chemical studies. Mutations in CD19 are associated with severe immunodeficiency syndromes characterized by diminished antibody production. CD19 has been shown to interact with: CD81, CD82, Complement receptor 2, and VAV2.

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$ 200.00
$ 375.00
Cat# PBV11489r-10
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