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Human CellExp™ B7-H6, human recombinant

Natural cytotoxicity triggering receptor 3 ligand 1

     
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Product info
Primary Accession Q68D85
Calculated MW 80 kDa
Additional Info
Gene ID 374383
Other Names B7-H6, Natural cytotoxicity triggering receptor 3 ligand 1, B7H6, B7 homolog 6, NCR3LG1
Gene Source Human
Source HEK 293 cells
Assay&Purity SDS-PAGE;≥ 98%
Recombinant Yes
Target/Specificity NCR3LG1
Application Notes Reconstitute in 1X PBS to the desired protein concentration.
Format Lyophilized
Storage -20°C; Lyophilized from 0.2 µm-filtered solution in PBS.
Citations (0)

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Background

B7-H6 is a glycosylated member of the B7 family of immune costimulatory proteins. Orthologs in mouse and rat have not been identified. The Ig-like V domain mediates 1:1 stoichiometric binding of B7-H6 to NKp30 expressed on NK cells. It does not show binding to NKp44, NKp46, or NKG2D. Ligation of NKp30 by B7-H6 induces NK cell activation and target cell cytolysis. B7-H6 is expressed on a wide range of hematopoietic, carcinoma, and melanoma tumor cells, which is consistent with the detection of NKp30 binding sites on many tumors. The expression of NKp30 ligands on tumor cells correlates with tumor cell sensitivity to NKp30-dependent cell lysis.

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$ 145.00
$ 395.00
Cat# PBV11490r-10
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